[5][6] In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities.

The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.

The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis.

Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

[7][8][9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.