86312398ENSG00000129993ENSMUSG00000006362O75081O54972NM_005187NM_175931NM_001109873NM_009824NM_177289NP_005178NP_787127NP_001103343NP_033954NP_796263Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded by the CBFA2T3 gene.

[5][6] The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies.

In addition, this gene is a putative breast tumor suppressor.

Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.

[6] CBFA2T3 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.