1A81, 1SY6, 1XIW, 2ROL91612501ENSG00000198851ENSMUSG00000032093P07766P22646NM_000733NM_007648NP_000724NP_031674CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.

[5][6] The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex.

This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11.

[13] This article incorporates text from the United States National Library of Medicine, which is in the public domain.