1H4L, 1UNG, 1UNH, 1UNL, 3O0G885112569ENSG00000176749ENSMUSG00000048895Q15078P61809NM_003885NM_009871NP_003876NP_034001Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.

The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions.

The p25 form accumulates in the brain neurons of patients with Alzheimer's disease.

This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

[6] In melanocytic cells CDK5R1 gene expression may be regulated by MITF.