2VZ6, 3SOA, 5IG381512322ENSG00000070808ENSMUSG00000024617Q9UQM7P11798NM_171825NM_015981NM_001363989NM_001363990NM_001369025NM_001286809NM_009792NM_177407NP_057065NP_741960NP_001350918NP_001350919NP_001355954NP_001273738NP_033922NP_803126NP_001390238NP_001390241Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMKIIα), a.k.a.

Ca2+ signaling is crucial for several aspects of synaptic plasticity at glutamatergic synapses.

This enzyme is composed of four different chains: alpha, beta, gamma, and delta.

The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning.

[7] According to a 2018 study by Bruno Reversade, the recessive mutation of CAMK2A in humans cause a syndrome of severe intellectual disability with growth retardation.