2EYI, 2EYN, 2N8Z, 2N8Y87109711ENSG00000072110ENSMUSG00000015143P12814Q7TPR4NM_001102NM_001130004NM_001130005NM_134156NM_001346669NM_001379075NM_001379076NP_001093NP_001123476NP_001123477NP_001093.1NP_001333598NP_598917NP_001366004NP_001366005Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.

[5] Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins.

Alpha-actinin-1 is an F-actin cross-linking protein – a bundling protein that is thought to anchor actin to a number of intracellular structures.

[6] Alpha-actinin-1 is a non-muscle cytoskeletal isoform found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane.

In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.