[5][6][7] This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle.

The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis.

The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome.

[7] Furthermore, CEP135 is also required for the centriolar localization of CEP250.

This article on a gene on human chromosome 20 is a stub.