Owned by Corus Entertainment, CFIQ's studios are located at the Corus Quay Building in Toronto; despite the station's city of licence being a suburban community north of the city, the transmitter is located in the Niagara Region town of Lincoln, 60 kilometres (37 miles) southwest of Toronto.

[6] Several notable radio personalities were associated with the station during this era, including John Gallagher, "Tarzan Dan" Freeman, Pat Cochrane, Adrian Bell, Tony Monaco, Deanna Nason, Randy Taylor, Eric Hollo, Kenny 'The Hitman' Caughlin, Roger Kelly and the Toronto radio team of Jesse and Gene.

[7][8] As Talk 640, the station aired syndicated shows such as Joy Browne, Rhona Raskin, Dr. Laura and Live Audio Wrestling, along with local programming hosted by personalities such as Gene Valaitis, Jane Hawtin, Bill Carroll, Shelley Klinck, Marsha Lederman, Karen Horsman, Michael Coren, Dave Chalk, Spaceman Gary Bell and Roger Kelly.

Despite regular adjustments, including acquiring the radio broadcast rights to the Toronto Maple Leafs, the station received low ratings.

Later on, John Oakley replaced Scruff Connors, who had taken over from Humble and Fred; the latter pair left for hot adult contemporary station CKFM-FM in July 2003.

In 2004, due to low ratings (MOJO was typically hovering around a 1.4 share), the station moved away from the male-oriented imaging to a more general news and talk format as AM640 Toronto Radio.

Award-winning journalist Arlene Bynon was added to the ranks in 2006 to host the Saturday afternoon Toronto Weekend program, which expanded to include a Sunday edition as well.

AM640's Leafs play-by-play colour analyst Jim Ralph became co-host of The Bill Watters Show, which ran from 4pm – 7pm covering hockey issues and other major sports news as well, up until July 15, 2011.

On August 30, 2010, Arlene Bynon took over hosting duties for the 1pm - 2pm hour, with news anchor Tina Trigiani guest-hosting Friday afternoons.

Bill Carroll hosted the 4-7pm weekday slot in Toronto in addition to his a separate show on Los Angeles talk radio station KFI (which is also at 640 on the AM dial) One of the station's biggest draws was that it was the radio broadcaster of the Toronto Maple Leafs, which it networked into other markets.

The official changeover to Global News Radio 640 Toronto occurred on December 1, 2017, with CFMJ maintaining its talk format and on-air roster.

[14] The weekday talk show lineup included Greg Brady hosting Toronto Today in the morning drive slot followed by Kelly Cutrara, Alan Carter, Jeff McArthur, John Oakley, Alex Pierson and Ben O'Hara-Byrne, with Shane Hewitt in the overnight slot.

[15] Effective August 8, 2022, Carter and McArthur discontinued their shows in order to focus on their duties at Global Television.

[19] On November 27, 2020, Dwivedi announced on-air that she was leaving the show and Global, filing a complaint with the Canadian Human Rights Commission alleging that the station had allowed its on-air talent and callers to spread "false narratives" about refugees, Muslims and other groups on air, unchallenged, and refused to enforce journalistic standards on talk radio resulting in her "receiving an increase in racist comments and violent threats".

In her resignation letter, she stated “I can no longer be part of an ecosystem that tolerates and in some cases, actively sows division and discord... As a female, racialized journalist, I have been subject to rape threats against me and my 17-month old daughter and absolutely abhorrent statements from members of the public when I attempt to counter and correct the misinformation and false narratives promoted by other hosts and guests on the station.”[20][21] Mike Stafford remained as the show's host, with rotating guest co-hosts, until June 2021 when he was fired, after 20 years at the station, for using a racial slur in an internal company group chat while commenting that Ontario Premier Doug Ford was likely to slip up and use the slur during his press conference.

[22][23] Stafford had previously been briefly suspended in 2019 after making derogatory comments about South Asians and Muslims on social media.

[24][25] Jeff Marek was offered a position with Sirius Satellite Radio and CBC's Hockey Night in Canada to host a new show.

Brian Duff from the NHL Network was the program's host for a period of time until he was replaced by TSN Hockey Insider Darren Dreger.

Like the Stafford Show, a main topic was introduced and then Tina took input from listeners via e-mail and phone calls.

Bill Carroll hosted the afternoon drive slot along with commentary from news anchor Sandy Salerno and producer Chris Chreston until early 2016.

For over 15 years, Gary Bell (nicknamed 'The Spaceman') hosted a show, broadcast on Saturday nights, that dealt with current events, numerology and conspiracy theories .

The show was cancelled, following its November 11, 2017 broadcast, when parent company Corus fired the late-night host citing complaints of anti-Semitic content.

Notable panelists included Maddie Di Muccio, Lisa Kinsella, Anne Lagacé Dowson, and Sophie Nadaeu.

Shane Hewitt hosted the show from a home studio in Airdrie, Alberta and was based out of CKNW 980 in Vancouver.