CKLF like MARVEL transmembrane domain-containing 1 (i.e. CMTM1), formerly termed chemokine-like factor superfamily 1 (i.e. CKLFSF1), has 23 known isoforms, the CMTM1-v1 to CMTM1-v23 proteins.
[1] Protein isoforms are variant products that are made by alternative splicing of a single gene.
[4] Studies have reported that the levels of CMTM1 (typically the CMTM1–v17 isoform[5]) are more highly expressed in breast, kidney, lung, ovary, liver (i.e. hepatocellular carcinoma), and salivary gland adenoid cystic carcinoma malignant tissues than the nearby normal tissues of these respective organs.
[5][4] According to the Human Protein Atlas, higher levels of CMTM1 expression in hepatocellular carcinoma tissues are associated with shorter survival times.
[6] In addition, the forced overexpression of CMTM1 in cultured glioblastoma cell lines increased their proliferation and invasiveness.