1K9J, 1SL6, 1XAR, 1XPH, 3JQH10332170786ENSG00000104938ENSMUSG00000031494Q9H2X3Q91ZX1NM_001144909NM_001144910NM_001144911NM_014257NM_214675NM_214676NM_133238NP_001138381NP_001138382NP_001138383NP_055072NP_573501C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene.

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein.

This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells.

Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

[6] This article incorporates text from the United States National Library of Medicine, which is in the public domain.