9099326427ENSG00000157613ENSMUSG00000027230Q96BA8Q9Z125NM_052854NM_011957NP_443086NP_036087CAMP responsive element binding protein 3 like 1, also known as OASIS, is a responsive element binding protein that in humans is encoded by the CREB3L1 gene.

[5] The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER).

However, upon stress to the ER, the encoded protein is cleaved, and the released cytoplasmic transcription factor domain translocates to the nucleus.

There it activates the transcription of target genes by binding to box-B elements.

[6] This article incorporates text from the United States National Library of Medicine, which is in the public domain.