Unirea Ungheni was founded in 1947 and played mostly in the district, regional and county championships.

Unirea won the Mureș County Championship for the first time in the 1992–93 season, but the team coached by Carol Erős failed to secure promotion to the third division, finishing below the sixteen teams with the best aggregate results after matches against Industria Sârmei Câmpia Turzii (0–3 away and 4–0 at home).

In 2012, the club withdrew from the third tier due to financial problems and was dissolved for the second time in their history.

In the 2023–24 Liga III season, under the command of Florentin Petre, with experienced players such as István Fülöp, Victoraș Astafei, Amancio Fortes, Cătălin Savin together with Ovidiu Horșia, Paul Ganea, Yvan Ndiesse, Abel Popa, Silviu Boar, Cristian Gherasim, Ioan Bârstan among others, the club finished in 3rd place during the regular season, but finished 2nd in the Play-off round of Series IX, overtaking ACS Mediaș and qualifying for the promotion play-offs.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.