The Ca' da Mosto is a 13th-century Venetian-Byzantine style palace, the oldest on the Grand Canal, located between the Rio dei Santi Apostoli and the Palazzo Bollani Erizzo, in the sestiere of Cannaregio in Venice, Italy.

[2] The most famous da Mosto was Alvise Cadamosto, an Italian explorer who worked with slave traders in Portugal, and who was born in the palace in 1432.

[3] Between the 16th and the 18th centuries, the Ca' da Mosto housed the well-known Albergo Leon Bianco ("White Lion Hotel").

The Ca' da Mosto sat empty for decades prior to 2019, with the high waters of the canal having breached its basement.

According to an interview in The Lady, the palace is admired by Francesco da Mosto, a descendant of its eponymous former owners, and is the Venetian building he would most like to see restored.