The church is notable particularly for the Cornaro Chapel, an important example of Early Renaissance architecture, added by Mauro Codussi during the 1490s.

[2] The church stands on the Campo dei Santi Apostoli at the beginning of the Strada Nuova (New Road).

[citation needed] In the middle of the 16th century the church briefly housed the Catecumeni, a Venetian fraternity for those wishing to convert to Christianity, before they established a permanent home at San Gregorio in 1571.

[citation needed] During the early 18th century, Andrea Tirali added detailing, including the onion dome, to the campanile which itself had been a late 17th-century addition.

One chapel has the funeral monument of Count Giuseppe Mangilli, designed by Luigi Trezza with bust by Angelo Pizzi.