[1]: 262–263 Cacamatzin died during the retreat of Spanish conquistador Hernán Cortés, on La Noche Triste.

[1]: 302 [3]: 90 While staying in the Axayácatl palace, the Spaniards discovered the room where the treasures of Moctezuma's grandfather were found.

After the answer, expeditions were organized to the regions of Zacatula, Pánuco and Coatzacoalcos; Cortés also demanded that Moctezuma ask all his vassals to immediately pay all available gold.

However, Moctezuma, enraptured by the Europeans, and not wanting to see Tenochtitlan under war, alerted Cortés, who tried to make peace with the Lord of Tetzcuco.

Moctezuma, through messengers, interceded in favor of Cortés and ordered Cacamatzin to be asked once again not to attempt rebellion against the Spanish.