Caco-2

[2] The line was developed in 1977 by Jorgen Fogh at the Sloan-Kettering Institute for Cancer Research.

[2] The research application of Caco-2 cells was developed during the 1980s by Alain Zweibaum group at INSERM, France as well as Ismael Hidalgo, at the Borchardt laboratory, University of Kansas and Tom Rauband at the Upjohn Company.

The first publication of the discovery of the spontaneous enterocyte like differentiation was published by Alain Zweibaum group in 1983.

[4][8] The Caco-2 monolayer can be used as an in vitro model of the human small intestinal mucosa to predict the absorption of orally administered drugs.

[9] A correlation between the in vitro apparent permeability across Caco-2 monolayers and the in vivo fraction absorbed has been reported.