Cafayate (Spanish pronunciation: [kafaˈʎate]) is a town located at the central zone of the Valles Calchaquíes in the province of Salta, Argentina.

The town is an important tourist centre for exploring the Calchaquíes valleys, and because of the quality and originality of the wines produced in the area.

The Cafayates were a tribe of the Diaguita-Calchaquí group, which, together with the related Tolombón, inhabited the Valles Calchaquíes prior to the arrival of the Spanish Conquistadores.

The wines produced in the region benefit from the low-humidity mild weather of the valleys that receive an average of less than 250 mm of precipitation per year.

National Route 40 goes for 165 kilometres from Cafayate to Cachi, another of the most visited points in the area (please note that this stretch of RN40 is not paved and should be avoided during the raining season).