Cajal body

They were first reported by Santiago Ramón y Cajal in 1903, who called them nucleolar accessory bodies due to their association with the nucleoli in neuronal cells.

Later on, they were forgotten and rediscovered multiple times independently which led to a state where scientists from different research fields used different names for the same structure.

The bodies were even predicted to consist of ribonucleoproteins since treatment of cells with protease and RNase together, but not alone, caused dramatic changes to the structure of CBs.

[6] The cells in which Cajal bodies are most apparent usually demonstrate high levels of transcriptional activity, and are often dividing rapidly.

[citation needed] CBs contain high concentrations of splicing small nuclear ribonucleoproteins (snRNPs), possibly indicating that they function to modify RNA after it has been transcribed from DNA.