They include proteins from several structurally different families: chloride channel accessory (CLCA),[3] bestrophin (BEST),[4][5] and calcium-dependent chloride channel anoctamin (ANO or TMEM16) channels[4][5][6][7] ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal, which are proteins which serve as intestinal pacemakers for peristalsis.

[8] These eukaryotic proteins are "required for normal electrolyte and fluid secretion, olfactory perception, and neuronal and smooth muscle excitability" in animals.

[9][10] Members of the Ca-CIC family are generally 600 to 1000 amino acyl residues (aas) in length and exhibit 7 to 10 transmembrane segments (TMSs).

The role of TMEM16A in gliomas and the potential underlying mechanisms were analyzed by Liu et al. 2014.

The reactions believed to be catalyzed by channels of the Ca-ClC family are:[16]Cl− (out) ⇌ Cl− (in)andCations (e.g., Ca2+) (out) ⇌ Cations (e.g., Ca2+) (in)CaCCs that are known to occur in humans include: As of this edit, this article uses content from "1.A.13 The Epithelial Chloride Channel (E-ClC) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL.