81912328ENSG00000164615ENSMUSG00000021501P49069P49070NM_001745NM_007596NP_001736NP_031622Calcium modulating ligand (CAMLG or CAML), also known as calcium-modulating cyclophilin ligand, is a signalling protein recognized by the TNF receptor TACI.

When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin.

The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium.

This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

This article on a gene on human chromosome 5 is a stub.