Calico is an unincorporated community in Pitt County, North Carolina, United States.

[1] It is located 16 miles (26 km) south of Greenville along North Carolina Highway 102.

A post office called Calico was established in 1882, and remained in operation until 1902.

[2] Calico was so named on account of the community being a trading point where calico was sold.

This article about a location in Pitt County, North Carolina is a stub.