The 41st district currently includes most of the wealthy, majority-white parts of the Coachella Valley, including the cities of Palm Springs, Rancho Mirage, Palm Desert, Indian Wells, and La Quinta.

The district then stretches through the sparsely inhabited regions of the San Jacinto Mountains before taking in the vast majority of Corona and its sphere of influence, including Norco, Lake Elsinore, Canyon Lake, and portions of Eastvale.

The 41st and 48th are partitioned by Ortega Highway, Tenaja Truck Trail, NF-7506, Tenaja, San Mateo Creek, Los Alamos Rd, Und 233, S Main Dv, Wildomar, Grand Ave, Rancho Mirlo Dr, Copper Canyon Park, 42174 Kimberly Way-35817 Darcy Pl, Escondido Expressway, Scott Rd, 33477 Little Reb Pl-33516 Pittman Ln, Keller Rd, Menifee Rd, Clinton Keith Rd, Max Gilliss Blvd, Highway 79, Borel Rd, Lake Skinner, Warren Rd, Summitville St, Indian Knoll Rd, E Benton Rd, Rancho California Rd, Overhill Rd, Green Meadow Rd, Crossover Rd, Exa-Ely Rd, Denise Rd, Wiley Rd, Powerline Rd, Wilson Valley Rd, Wilson Creek, Reed Valley Rd, Centennial St, Beaver Ave, and Lake Vista Dr.

The 41st district takes in the cities of Wildomar, Canyon Lake, Menifee, Palm Springs, Palm Desert, La Quinta, Lake Elsinore, Norco, Calimesa, Rancho Mirage, Indian Wells, most of Corona, southern Eastvale, and western Riverside, as well as the census-designated places Cherry Valley, Nuevo, Homeland, Sage, Idyllwild-Pine Cove, Woodcrest, Coronita, El Sobrante, El Cerrito, Lake Mathews, Temescal Valley, Warm Springs, Lakeland Village, Lakeview, Romoland, Green Acres, French Valley, Anza, and Mountain Center.

The district formerly represented parts of the Inland Empire region, San Bernardino Mountains, and Mojave Desert, stretching from portions of the city of San Bernardino north to the Nevada border and east to the Colorado River.