The California tree frog has conspicuous toe webbing and pads, and its dorsal skin is roughened and warty.

[4] California tree frog is not considered threatened by IUCN: it is a relatively common species with broad distribution, and there are no major threats, except perhaps UV radiation that reduces embryonic survival.

[1] Another possible threat to this frog species is habit fragmentation which could contribute to a lack of genetic diversity throughout populations in different areas.

[5] Genetic evidence from over 200 individual members of the species, collected from locations across multiple of California's unique biomes, suggests that these frogs originated at the eastern end of the Transverse Ranges.

The same research found that the California tree frogs' genetic foundation dates back to Pleistocene Epoch.