Callosa de Segura (Spanish pronunciation: [kaˈʎosa ðe seˈɣuɾa]) is a municipality in the comarca of Vega Baja del Segura in the Valencian Community, Spain.

Callosa de Segura is a traditional Spanish-speaking town located north-west of Orihuela.

The Saint Martin's Church, dating from the 16th - 18th centuries, has a blue decorated dome.

The chapel of the church contains some pieces of gold work by Miguel de Vera.

The museum has four sections: The economy of the town is dependent mostly on agriculture and manufacturing; hemp based cordage products being an important part of this.