Cambarellus lesliei is a species of crayfish in the family Cambaridae.

[1] This is listed as a least-concern species by the International Union for Conservation of Nature (IUCN).

It is common in its range, and though it faces several threats, none are considered to be major.

[1] The crayfish is listed as a vulnerable species by NatureServe, because it has a limited range, a fragmented population, and threats to its survival that have likely led to declines in some subpopulations.

[2] Mobile Bay and its associated rivers host heavy shipping traffic and are affected by habitat disturbance and pollution.