The oldest part of the Camden and Burlington County Railway's network was the original main line of the Burlington and Mount Holly Railroad and Transportation Company, constructed between 1848 and 1863 and running from Burlington, New Jersey, and Pemberton, New Jersey, via Mount Holly, New Jersey.

[1] Its successor, Camden and Burlington County Railroad, built west from Mount Holly to Pavonia in 1867, giving it two connections to the Camden and Amboy Railroad main line.

[2] The Mount Holly, Lumberton and Medford Railroad and Vincentown Branch of the Burlington County Railroad constructed branches to Medford, New Jersey, and Vincentown, New Jersey, respectively.

[3] The Camden and Burlington County Railway was incorporated on October 4, 1915.

[7] The Camden and Burlington County Railway owned the following lines:[6]