Slightly offset from the Mid-City end is the beginning of Canal Boulevard, which extends to the shore of Lake Pontchartrain via the Lakeview neighborhood.
Canal Street's downtown segment serves as the hub of the city's public transit system or RTA, with numerous streetcar and bus route terminals.
Local or regional department stores Maison Blanche, D. H. Holmes, Godchaux's, Gus Mayer, Labiche's, Kreeger's, and Krauss anchored numerous well-known specialty retailers, such as Rubenstein Men's Store, Adler's Jewelry, Koslow's, Rapp's, and Werlein's Music, as well as bookstores, drugstores, Kress, Woolworth's, and others.
The department stores began as sellers of fabric, notions, and accessories, with extensive floor space and glass windows.
However, national trends disfavoring downtown retail finally caught up with Canal Street — with a key assist from the regional economic depression of the mid-80s (the Oil Bust).
The mall contains a Saks Fifth Avenue, the Theatres at Canal Place, a food court, and approximately 45 high-end retailers including Anthropologie, Brooks Brothers, Michael Kors, and Morton's the Steakhouse.
Theaters and movie houses were clustered around the intersection with Rampart Street, with the neon marquees of the Saenger, Loews State, Orpheum, and Joy casting multi-colored light nightly onto surrounding sidewalks.
It is said that the world's first movie theater (that is, the first business devoted specifically to showing films for profit) was "Vitascope Hall", established on Canal Street in 1896.
[4] Canal Street began to accommodate large convention hotels, such as the Sheraton New Orleans and the JW Marriott.
At least two other high-rise hotels are just off Canal Street, the Roosevelt in the Central Business District (CBD) and the Monteleone in the French Quarter.
In recent years the street has welcomed the addition of numerous new anchor enterprises, including the Ritz-Carlton New Orleans, luxury apartments at 1201 Canal, the New Orleans Bio-Innovation Center, the rehabilitated Joy Theater, the Saint Hotel, the Audubon Nature Institute's Audubon Insectarium, and the Astor Crowne Plaza.
After exiting downtown, Canal Street runs for its remaining length through the Mid-City neighborhood, part of which is now designated as BioDistrict New Orleans, a state-chartered economic development district created to encourage growth in the region's biomedical sector.
Construction of two new teaching hospitals, the University Medical Center and a U.S. Department of Veterans Affairs regional facility, involving the expenditure of approximately $2 billion, is now underway in the BioDistrict.