Northern and western parts of the Cape Region are rural areas dominated by farmland and wetlands.

A large portion of the region is low-lying Southern swamps and wetlands, notably found in Prime Hook National Wildlife Refuge, Cape Henlopen State Park, and along Delaware Route 1 within Delaware Seashore State Park.

There are several navigable waterways that flow through the region: Situated on the Atlantic Coastal Plain, Rehoboth Beach's weather is moderated by the Atlantic Ocean, Delaware Bay and the Rehoboth Bay.

[2] The Cape Region tends to be more affluent than western parts of Sussex County.

The majority of the area generally identified as the Cape Region is located in Delaware's 6th Senate district, with the sparsely populated southwestern communities of Hollyville and Hollymount located in Delaware's 19th Senate district.