The building was originally a private house known as "The Priory" which was designed by John Nash and completed in 1789.

[1][2] It was converted into a hospital, based on designs by John Teifion James Williams, and re-opened in March 1922.

[1] A new outpatients department was opened by Dame Margaret Lloyd-George in September 1923.

[1] It joined the National Health Service in 1948 and the interior was completely rebuilt in the early 1960s.

[3] After outpatient services were transferred to Cardigan Integrated Health Centre, it closed completely on 10 December 2019.