Formerly a reporter for The Wall Street Journal, she co-founded and works for the organizations Open Philanthropy and Good Ventures.

[5] While studying, she contributed articles to her hometown newspaper, the Evansville Courier & Press, and completed an internship at the Minneapolis Star Tribune.

[5] Tuna currently works full-time at Good Ventures, the private foundation she co-founded with her husband, and is the chair of Open Philanthropy, a spinoff resulting from a collaboration between Good Ventures and GiveWell, that she co-founded with her husband and Holden Karnofsky.

[4][7] Tuna was included in Time's "100 Most Influential People in AI 2024" for her role as the president of Open Philanthropy.

[8] Tuna met internet entrepreneur Dustin Moskovitz on a blind date, and they got married in 2013.