After playing college football at Wyoming, he was signed by the Saints as an undrafted free agent in 2019.

Granderson signed with the New Orleans Saints as an undrafted free agent following the 2019 NFL draft on May 10, 2019.

[8] He played in 16 games with four starts in 2022, recording 53 tackles and 5.5 sacks, good for fourth on the team.

On September 23, 2023, Granderson signed a four-year, $52 million contract extension with the Saints.

[9] Granderson was sentenced to six months in prison on July 11, 2019, after pleading no contest to sexual battery and unlawful contact from an incident in 2018 involving two women.