Pettis attended JSerra Catholic High School in San Juan Capistrano, California.

[4][5] As a senior in 2017 against the Oregon Ducks, he broke the record for most career punt return touchdowns in NCAA history.

[13] In the season-opener against the Minnesota Vikings, Pettis made his NFL debut and caught two passes for 61 receiving yards and a touchdown.

[14] On December 29, 2018, Pettis was placed on injured reserve after suffering a knee injury.

[21] In his first game played as a Giant, on December 27, 2020, against the Baltimore Ravens, Pettis finished with two receptions for 33 yards.

[25] In Week 7 against the Carolina Panthers, Pettis had five catches for 39 yards and a touchdown while adding the 16-yard pass to Daniel Jones.

[28] On October 14, Pettis caught four passes for 84 yards and the Bears’ only touchdown, during a 12–7 loss to the Washington Commanders.

[36] His father, Gary Pettis, played in Major League Baseball (MLB) and is a coach for the Houston Astros.