He played college football for the NC State Wolfpack and South Florida Bulls, and was selected by the Green Bay Packers in the fifth round of the 2018 NFL draft.

[10] He made his NFL debut in the Packers' season opener against the Chicago Bears on September 9, 2018, recording a 21-yard kick return in the 24–23 victory.

[12] He started his first career game in place of the injured Randall Cobb in a Week 4 win over the Buffalo Bills, catching one pass for 38 yards.

[13] Still starting in place of Cobb during a Week 5 loss to the Detroit Lions, Valdes-Scantling had a breakout performance, notching seven receptions for 68 yards and a touchdown.

[18][19] In Week 3 against the Denver Broncos, Valdes-Scantling caught six passes for 99 yards and his first receiving touchdown of the season as the Packers won 27–16.

[20] During Week 7 against the Oakland Raiders, Valdes-Scantling finished with two catches for 133 receiving yards, including a 74-yard touchdown as the Packers won 42–24.

[25] In Week 11 against the Indianapolis Colts, Valdes-Scantling recorded a key 47-yard catch on a late fourth quarter drive that resulted in a game-tying field goal by Mason Crosby.

[37] In the AFC Championship Game, Valdes-Scantling caught six passes for 116 yards and a touchdown helping the Chiefs defeat the Cincinnati Bengals 23–20.

[44] On October 15, 2024, following the Bills' acquisition of wide receiver Amari Cooper in a trade with the Cleveland Browns, Valdes-Scantling was released.