[4] Kpassagnon received an invitation to the Senior Bowl and made two combined tackles and a sack, helping the South clinch a 16–15 defeat over the North.

Representatives from 18 NFL teams, including six defensive line coaches, attended to scout Kpassagnon as the feature prospect, two Villanova teammates, and seven other players from smaller schools.

[6] Kpassagnon had private workouts and visits with ten NFL teams, that included the Dallas Cowboys, Detroit Lions, Carolina Panthers, Cincinnati Bengals, Atlanta Falcons, New England Patriots, Baltimore Ravens, Washington Redskins, New Orleans Saints, and Pittsburgh Steelers.

[14] He competed with Rakeem Nuñez-Roches, Jarvis Jenkins, Allen Bailey, and David King throughout training camp for the vacant starting defensive end job left by the departure of Jaye Howard.

[15] Kpassagnon was named the backup right outside linebacker behind Dee Ford with the usual starter, Tamba Hali, on the physically unable to perform list to begin the regular season.

On December 31, 2017, with the division title and the fourth seed clinched, Chiefs head coach Andy Reid rested the majority of the teams starters, giving Kpassagnon the chance to make his first career start against the Denver Broncos.

[16] On January 19, 2020, against the Tennessee Titans in the AFC Championship Game, Kpassagnon sacked quarterback Ryan Tannehill twice during the 35–24 win.

[18] In Week 16 of the 2020 season against the Falcons, Kpassagnon tipped a potential game-tying field goal attempt by Younghoe Koo to seal a 17–14 win for the Chiefs.