Carlisle High School is a comprehensive public high school serving students in grades 7 through 12 in the rural community of Carlisle, Arkansas, United States.

The school is accredited by the Arkansas Department of Education (ADE).

The assumed course of study follows the ADE Smart Core curriculum developed the Arkansas Department of Education (ADE), which requires students to complete at least 22 credit units before graduation.

Students engage in regular (core) and career focus courses and exams and may select Advanced Placement (AP) coursework and exams that may lead to college credit.

The Bisons school athletic activities include football, golf (boys/girls), cross country (girls), basketball (boys/girls), swimming (boys/girls), and track and field (boys/girls).