[2] In 2019, Vargas made 15 starts for the Low–A Mahoning Valley Scrappers, registering a 6–4 record and 4.52 ERA with 71 strikeouts across 77+2⁄3 innings of work.
[5] In April 2021, Vargas underwent ulnar collateral ligament reconstruction (Tommy John surgery),[6] causing him to miss the entire 2021 season.
He began the 2022 season on the rebranded Cleveland Guardians' major league 60-day injured list as he continued to recover from surgery.
The Guardians traded Vargas to the Arizona Diamondbacks on November 15, 2022, in exchange for minor league pitcher Ross Carver.
[10] On November 22, 2023, the Diamondbacks traded Vargas along with Seby Zavala to the Seattle Mariners in exchange for Eugenio Suárez.