When the Bulletin was absorbed into the San Francisco Call in 1929, Morse lost his job, soon after marrying his first wife, Patricia DeBall.

He soon was offered a job at KGO, the San Francisco outlet of NBC's Blue Network, and began his radio career scripting House of Myths.

Morse began work on NBC Mystery Serial, which included such episodes as "Captain Post: Crime Specialist" and "Case of the One-eyed Parrot".

He also did four programs based on San Francisco Police Department files: Chinatown Squad, Barbary Coast Nights, Killed in Action and To the Best of Their Ability.

Morse worked closely with San Francisco Police Chief William J. Quinn, who narrated all four series.

The two series were almost polar opposites; "One Man's Family" was a daily soap opera, targeted at housewives, and "I Love a Mystery" was an adventure serial for adolescents and lovers of the macabre.

Morse created and wrote the soap opera Family Skeleton, which ran on CBS radio in 1953–1954.

Morse brought One Man's Family to television (1949–52), years before it left the airwaves with the end of the Golden Age of Radio.

Three of his books, Killer at the Wheel, A Lavish of Sin and Stuff the Lady's Hatbox were based on I Love a Mystery.