[1] She obtained a set of a four-tentacle harness identical to Octavius's, which she upgraded by adding a force-field that protected her from any exterior attacks, but allowed her tentacles to freely go through.

She tried but failed to blackmail her way into gaining Trainer's data by stealing a serum that could cure a seriously ill Mary Jane Watson, resulting in her being beaten heavily by Spider-Man and revealing she was working for the mysterious Master Programmer.

She hired the Looter, Override and Aura, and the Pro to assist her in this, as well as Stunner (Octavius's lover/henchwoman), and eventually succeeded in defeating Smythe and gaining the technology she needed before the Scarlet Spider thwarted her.

The cult group known as The Hand, working for Rose, dug up Octavius' corpse and brought him back from the dead, albeit with large mental gaps.

They regrouped to a dock where a small army of Tinkerer's clients where waiting (consisting of Boomerang, Constrictor, Crimson Dynamo IX, Crossfire, Eel II, Goldbug, Grim Reaper, King Cobra, Mentallo, Scorcher, Scorpion, Shocker, Spider-Slayer XIX, Trapster, and Wizard).

[14] Lady Octopus has been hired by Walter Declun (a former member of Damage Control) to assist Absorbing Man, Hydro-Man, Killer Shrike, a Mandroid, Porcupine II, and Rock to defend him from Black Panther and the Fantastic Four after they uncovered his plot to destabilize all of Wakanda on Doctor Doom's behalf.

Carolyn then mentioned to Janice Lincoln about the e-mail about the refrigerator where there is dairy products inside where she was planning an organic vegan cheeseburger night on Friday.

[22] During the "Gang War" storyline, Lady Octopus accompanied Beetle, Scorpia, and Trapstr in providing aid to White Rabbit and her henchman Kareem when Black Mariah's group attacks the warehouse that they were in.

[26] During the fight in Central Park, Lady Octopus and Electro fought Shotgun and Rabble as Spider-Man and his allies arrive.

[27] When Tombstone orders White Rabbit to have the Sinister Syndicate and those on their side pull out of Central Park, Lady Octopus briefly entangles Miles Morales on the way out.

[28] Lady Octopus appeared as a member of a Multiversal group called the Sinister Squadron where they attacked the Spider-Society before it can be formed.

Instead, she wears a special harness, similar to the one used by the original Doctor Octopus, which incorporates four strong and highly-resistant mechanical appendages, which can be extended or retracted at will.

Additionally, Lady Octopus possesses a genius-level intellect; having studied robotics, information technology, applied physics, and mechanical engineering.

Years after Otto Octavius died, Trainer assumes the mantle of Doctor Octopus and attempts to create mutant soldiers.