The first time, in the year 1569 by Juan de Trejo, but due to constant attacks from the indigenous population, it was abandoned, only to be refounded three years later (1572) by Juan de Salmanca.

Carora City flourished in colonial times, and grew to a population of nearly 10,000.

As of 1911, the neighboring country was devoted principally to raising horses, mules and cattle; in addition to hides and leather, it exported rubber and other forest products.

Carora City has been the birthplace of notable people in many fields.

Notables include uitarist players Alirio Diaz and Rodrigo Riera; historians Guillermo Moron, Ismael Silva Montañes, Ambrosio Perera; lawyers Ambrosio Oropeza, Juan Oropeza, Antonio Oropeza; health science Dr. Pastor Oropeza; lawyer and one of the writers of the 1961 Venezuelan Constitution Jose "Cheito" Herrera Oropeza; and Héctor Mujica, writer, journalist, co-founder of The Venezuelan.