The product line focuses on The Powerpuff Girls features Blossom, Bubbles, and Buttercup, three superheroes whose purpose is to reduce crime in between living a normal childhood.

The Lego construction toy range was based on the TV series and developed in collaboration with Cartoon Network Enterprises.

As part of the marketing campaign, The Lego Group released two toy sets based on the television show.

Minifigures were released as well, including Princess Morbucks, Octi, Donny the Unicorn, Mojo Jojo, Blossom, Bubbles, and Buttercup.

[17] In 2018, The Lego Group announced a partnership with Cartoon Network to create a licensing and merchandising programme based on The Powerpuff Girls television series, which was released on 24 August 2018.

The set included Lego minifigures of Mojo Jojo, Blossom and Buttercup along with Donny the Unicorn buildable figure.

[18][5] A pair of The Powerpuff Girls-themed packs for the toys-to-life video game Lego Dimensions were released on September 12, 2017.

episode for Lego Dimensions that included The Powerpuff Girls fighting the Gremlins in Jump City.