Carysfort is a coral reef located within the Florida Keys National Marine Sanctuary.

It lies to the east of Key Largo, within the Key Largo Existing Management Area, which is immediately to the east of John Pennekamp Coral Reef State Park.

Several charts and other publications of the late 18th and early 19th centuries spelled the name of the reef as "Carysford", with some sources giving the ship's name as Carysford, but "Carysfort" was standard for the reef by the middle of the 19th century.

The United States Lighthouse Board reported in the 1850s that "Carysfort Reef picks up twenty percent of all the wrecks between Cape Florida and the Tortugas, a space of 200 miles (320 km)."

A well-known early wreck, discovered in 1939, is that of HMS Winchester, which was driven onto the reef in 1695 by a hurricane.