It was built by the turn of the 20th century by a Spaniard named Justo Bernedo and his wife Isabel Macias, a Filipina from Dipolog, where they raised their nine children together.

The Bernedo house largely retained its original structure, only undergoing a minor renovation shortly after the end of World War II.

[citation needed] Following the death of the last of the nine surviving Bernedo-Macias siblings in 2008, the Bernedo house was closed permanently.

The lower floor, which was said to be a small storage house or warehouse (commonly known as a bodega), served as a venue for visual art and photography exhibits.

[2][3] As of 2024, Casa Bernedo and, to a great extent, the Dipolog City Center for the Culture and the Arts were closed to the public and were put up for sale.