The Casa Portela Museum (Spanish: Museo Casa Portela) is a historic house and local history museum located in Vega Baja Pueblo, the administrative and historic center of the municipality of Vega Baja, Puerto Rico.

The museum consists of a historic home locally known as the Portela House (Casa Portela) and an adjacent modern museum building located in a revitalized historic city block bordered by Hostos Street to the east, and the José Julián Acosta and Betances Streets to the north and south, respectively.

[2] The museum collections include pieces from the history of the municipality of Vega Baja from the time of its indigenous Taino inhabitants to modern times, general information about the geography and nature of the region, and notable memorabilia and personal belongings of some of the most famous figures from Vega Baja, such as the Trio Vegabajeño.

The museum was established in 1998 when the municipal government acquired abandoned building lots located next to a historic house formally owned by the local Portela family.

The modern museum building dates from 2004 and it was designed by architect Ángel Cocero Cordero.