The Casa Cisneros is a palace located on the Plaza de la Villa in Madrid, Spain.

Built in Plateresque style in 1537, at the request of Benito Jiménez de Cisneros, a 16th-century architect and nephew of Cardinal Cisneros (statesman and whose founder of founded the Complutense University), it is named in his honor.

The facade on calle Sacramento, originally the main entrance, is of the most significant historical and artistic value although somewhat modified during the 1909 renovations.

According to tradition, this palace served as a prison for the controversial royal secretary to King Philip II of Spain, Antonio Perez.

and General Ramón María Narváez, 1st Duke of Valencia was a famous resident who here in 1868.