The Castello di San Giorgio is part of the Ducal palace of Mantua.
Ludovico III Gonzaga gave over his rooms in the "Corte Vecchia" to pope Pius II for the Council of Mantua in 1459 - that year, he commissioned Luca Fancelli to rebuild the castle as a palazzo rather than as a defensible castle.
In 1490 the castle became the site of the studiolo of Isabella d'Este, remaining there until she moved it to the "Corte Vecchia" in 1519-1522.
In 1810 the Tyrolean fighter Andreas Hofer was imprisoned in the castle before his execution by the Kingdom of Italy.
Others pro-Risorgimento figures imprisoned there included Ciro Menotti and Teresa Arrivabene.