Càstro also translates to "castle" in Corsican, an Italian dialect similar to Sicilian.

The land surrounding Castronovo di Sicilia has been occupied since antiquity, with excavations having uncovered pottery dating back to the fifth century BCE.

The settlement was demolished by Roman occupiers in retaliation for slave revolts during the servile wars around 105 BCE.

The surviving population of Crastus dispersed over the entire territory of present-day Castronovo.

"[7][8][9] The fortification lies directly above a castle occupied by Roman, Byzantine, Arab, and Norman elites over the centuries, now known as Colle San Vitale.