Catasauqua High School participates in the Class AA division of PIAA District XI and in the Colonial League for sports.

A shrine in the high school's gymnasium houses a plaque and picture in recognition of each athlete inducted.

The school's football team competes in the Class AA division of PIAA District XI and in the Colonial League in the Lehigh Valley region of eastern Pennsylvania.

On each Thanksgiving Day, the Catasauqua Rough Riders play a non-league game against their rival, the Northampton High School.

The game is not sanctioned and does not count as a win or loss for official standings with regard to playoff consideration within the PIAA.

For a number of years through 1968, the Catasauqua–Northampton game was played on a neutral site, often at Scotty Wood Stadium on the campus of Muhlenberg College in Allentown.