Dieruff High School students may choose to attend Lehigh Career and Technical Institute for vocational training in the trades.

The Carbon-Lehigh Intermediate Unit IU21 provides the district with various specialized education services, including education for disabled students and hearing, speech and visual disability services, and professional development for staff and faculty.

The building was initially intended to serve as an Allentown School District junior high schooltown's growing population.

[5] Dieruff is one of two public high schools in Allentown and primarily serves students from the city's eastern part.

Dieruff High School has had many students who have won various individual awards and competitions, including: In 1965, amidst Cold War fears of American inadequacy in science education increased interest in astronomy before Apollo 11 Moon landing, Allentown School District erected a planetarium inside Dieruff High School.

[6] Following an acrimonious budget debate in 1991, all programs that were deemed nonessential were to be removed from the Allentown School District's budget, and public funding for the planetarium ended with its continued operation and upkeep left to private funding sources.

[7] Allentown School District's board approved a 2016-17 spending plan that added a number of teacher positions, including a planetarium director to reopen the shuttered planetarium at Dieruff High School.

The husky is named in honor of the ten men and women captured by the Japanese on Kiska Island in 1942 during World War II, some of whom were Allentown servicemen.