[1] The church is known for its artistic significance which includes works by Italian sculptor Santi Gucci.

[2] In 1925, papal bull Vixdum Poloniae unitas established the Diocese of Łomża, and the church became a cathedral.

[4] In 1991, Pope John Paul II gave a speech at the cathedral in Łomża.

The current vaulted church features a bell tower, six-sided altars, and is in the gothic style.

[2][5] The church also features a tomb from 1589 built by Santi Gucci for members of the Modliszowski family.