The Cathedral Church of St Andrew and St Demetrius (Spanish: Iglesia Catedral de los Santos Andrés y Demetrio) is a Greek Orthodox cathedral situated on Nicaragua Street in the neighbourhood of Hispanoamérica, district of Chamartín, Madrid, Spain, which belongs to the Orthodox Church of Constantinople.

In 1949, the Parish of St Andrew the Apostle (Parroquia del Apóstol San Andrés) was founded in the capital city Madrid, under the jurisdiction of the Patriarch of Constantinople.

Inside, like any other Eastern Orthodox church, an iconostasis with holy door separates the nave from the sanctuary.

The interior walls are entirely covered with colourful fresco paintings and elaborate decorative motifs made by Greek artists.

This article on an Eastern Orthodox church building in Spain is a stub.